International CdLS Awareness Day is observed each year to increase understanding and bring attention to Cornelia de Lange Syndrome (CdLS), an often misdiagnosed and little-known genetic condition. This special day serves as an opportunity for families, advocates, and healthcare professionals to unite in raising awareness and promoting early diagnosis, research, and support for individuals affected by CdLS. Activities include going live on social media, displaying educational flyers in public spaces, delivering presentations to civic organizations, healthcare providers, and schools, and engaging with local media through letters, articles, and interviews. Many also organize fundraising events, participate in social media campaigns, and host community gatherings to foster connections and provide resources for families. By coming together on CdLS Awareness Day, supporters help create a more informed and compassionate world for those living with this rare condition.