Our teenage son was treated for H. pylori. He later had a fundoplication. Following that, an Upper GI with small bowel follow through took 5 hours to reach the cecum (first part of the large intestine). He was put on Reglan but continues to have frequent severe abdominal pain.
H. pylori can certainly come back. A breath test or esophagogastroduodenoscopy (EGD) would be helpful. If that is normal and there doesn’t appear to be a problem with the Nissen fundoplication, a careful abdominal pain work up would be recommended. This includes looking at the kidneys, pancreas, ruling out Irritable Bowel Syndrome, etc.
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